Zohydro- New "Pure Vicodin" Painkiller Will Be Highly Addictive.

by mhurst220 — last modified Dec 28, 2011 04:02 PM

While Zohydro might be good for those in pain, the potential for abuse and addiction is off the charts.

Addiction experts are already on the alert about a new pain medication that's currently in the final stages of development.  The new drug contains a pure version of hydrocone, a highly addictive narcotic painkiller, and is reported to be 10 times stronger than Vicodin.  There are fears that a surge of abuse will follow release of the drug.  Zohydro will be addictive


Four companies are now testing the drug on patients.  Zogenix, a San Diego company, plans to begin selling the drug in early 2013 under the name Zohydro.  This will mark the first time that patients will have access to pure hydrocodone.  There are dozens of existing medications that contain hydrocone (like Vicodin), but all combine it with another drug such as Acetaminophen.

Zohydro will be extremely habit forming


Hydrocodone is a member of a category of drugs known as opiates.  These drugs, which are similar to opium, include other pharmaceutical drugs like oxycodone (marketed as OxyContin), codeine, and methadone as well as illegal drugs like heroin and morphine.  The DEA reports that hydrocodone is the second most abused prescription drug in the nation, with oxycodone in first place as the most abused drug.  


Critics of Zohydro are especially concerned that the drug has a time-released formula.  OxyContin was initially released with a similar formula and quickly became the drug of choice for substance abusers who crush the pills for a more intense effect.  Purdue Pharma, the maker of OxyContin, recently reformulated the drug to make it crush-resistant.  According to CBS News, this has caused many former OxyContin addicts to switch over to oxycodone and other drugs that are not time released. Purdue Pharma is also developing its own version of the new hydrocodone drug and has applied for a patent for extended release technology for the new drug.


Opiate-based painkillers have caused a national epidemic of abuse that has resulted in hundreds of pharmacy robberies and violent crimes as well as drug overdoses and deaths.  The CDC reports that prescription painkillers caused more than 15,000 deaths in 2008 as well as more than 86,000 emergency room visits.  Treatment for prescription painkiller abuse has risen by more than 430% over the past decade.


According to a 2008 study by the International Narcotics Control Board, the U.S. currently accounts for 99% of the world's hydrocodone consumption.  April Rovero, president of the National Coalition Against Prescription Drug Abuse, has expressed concern that this new drug could represent the next OxyContin.  "We just don't need this on the market," said Rovero.
 

When does Zohydro hit the market?

Avatar Posted by User at Jan 12, 2012 12:26 PM
Will it be available for existing Vicodin Medicare clients?

Zohydro

Avatar Posted by Ramsey at Feb 10, 2012 11:07 AM
Zohydro does not represent the first time that pure hydrocodone is available. Hydrocodone has been available for decades. Just because it is combined with acetaminophen doesn't make it not pure. Both drugs are freely available from the tablet. In fact, with a simple cold water extraction of Vicodin pills the hydrocodone can be completely isolated. Extended release hydrocodone like Zohydro represent just that, and extended release version. It is not a more pure version. People abuse hydrocodone like they do oxycodone and opioid abuse will not increase because of the addition of Zohydro. From a street value perspective the cost of any opioid is often on a per mg basis so it doesn't matter if you're getting 10 pills of Vicodin or 1-2 of Zohydro. It is all the same quantity of hydrocodone. The abuser will need less pills to get the same dose, but they will also have to contend with the extended release mechanism to get the drug all out at once. Not easy to do. Vicodin is an immediate release product so it takes only a few minutes in the gut to liberate all of that drug load. The abuser will migrate towards the cheapest and easiest high as they have done since they figured out they could get high eons ago. Oxycontin got a bad rap because its extended release mechanism could be easy and simply defeated. They finally reformulated and that product is reported to be much harder to defeat. The attention paid towards preventing abuse has come at a cost of making it harder for people in actual pain to get the relief they deserve. Zohydro will be approved on its ability to treat pain. Just like OxyContin, Exalgo, and Embeda. Cephalon/Teva and Purdue continue to pursue long acting formulations as well (along with a dozen other companies seeking abuse deterrent platform technologies). There has to be some responsibility placed on the abusers of these products because opioids aren't going to be pulled form the market.

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